Triethylamine → HCID 178521573、化合物

HRID 573135ノート

反応式

HRID 573135 の反応式
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([OH:8])[CH2:4][CH2:3]1.Br[CH2:10][CH2:11][O:12][CH2:13][CH2:14]Br.C(N(CC)CC)C>C(#N)C>[O:12]1[CH2:13][CH2:14][N:1]([C@H:2]2[CH2:7][CH2:6][C@H:5]([OH:8])[CH2:4][CH2:3]2)[CH2:10][CH2:11]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 21521Bis(2-bromoethyl) etherHCID 178511715HCID 178511715、化合物

生成物 1

HCID 178521573HCID 178521573、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

Trans-4-aminocyclohexanol (0.5 g), 1-bromo-2-(2-bromoethoxy)ethane (1.07 g) and triethylamine (2.42 mL) were dissolved in anhydrous acetonitrile (20 mL). The reaction mixture was heated at 60° C. overnight. The organic solvent was removed under vacuum. The residue was purified by flash column chromatography on silica gel eluting with 7-10% methanol in dichloromethane to give the title compound.

後処理

  1. customThe organic solvent was removed under vacuum
  2. customThe residue was purified by flash column chromatography on silica gel eluting with 7-10% methanol in dichloromethane

出典と根拠

ORDレコード
ord-5492562e5b94491f81b5f375de7209e6
出典データセット
uspto-grants-2015_05
特許番号
US09029404B2

反応ノート

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