反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][CH2:5]2.Cl[C:12]1[NH:16][C:15]2[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=2[N:13]=1.O>CC(N(C)C)=O.CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:12]1[NH:16][C:15]3[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=3[N:13]=1)[CH2:6][CH2:5]2参加物
5
反応条件
- 温度
- 150 °C
実験手順
A mixture of 5-bromoindoline (1 g) and 2-chloro-1H-benzo[d]imidazole (0.770 g) in DMA/DMF (5 mL, 3/2) was stirred at 150° C. for 12 h, treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (1.1 g).
後処理
- extractionextracted with AcOEt
- dry with materialThe organic layer was dried over MgSO4
- concentrationconcentrated under reduced pressure
- customThe residue was purified by silica gel column chromatography (AcOEt/hexane)
出典と根拠
- ORDレコード
- ord-382a041251144bd1a58a76f565fcab9f
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09029536B2
関連ノート
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