Iodoethane → Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate

HRID 573342ノート

反応式

HRID 573342 の反応式
[N+:1]([C:4]1[C:5]([C:9]([O:11][CH3:12])=[O:10])=[N:6][NH:7][CH:8]=1)([O-:3])=[O:2].[CH2:13](I)[CH3:14].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:13]([N:6]1[C:5]([C:9]([O:11][CH3:12])=[O:10])=[C:4]([N+:1]([O-:3])=[O:2])[CH:8]=[N:7]1)[CH3:14]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 178499180HCID 178499180、化合物

生成物 1

HCID 54775328Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
50 °C

実験手順

A mixture of methyl 4-nitro-1H-pyrazole-3-carboxylate (5.0 g), EtI (2.8 mL) and K2CO3 (8.1 g) in acetone (50 mL) was stirred at 50° C. for 4 h. After stirring at room temperature overnight, the mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (2.2 g).

後処理

  1. stirringAfter stirring at room temperature overnight
  2. filtrationthe mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (AcOEt/hexane)

出典と根拠

ORDレコード
ord-81918841e50747d593bb1ef17f22d105
出典データセット
uspto-grants-2015_05
特許番号
US09029536B2

反応ノート

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