Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate → Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate

HRID 573343ノート

反応式

HRID 573343 の反応式
[CH2:1]([N:3]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([N+:12]([O-])=O)[CH:5]=[N:4]1)[CH3:2]>CO.[Pd]>[NH2:12][C:6]1[CH:5]=[N:4][N:3]([CH2:1][CH3:2])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]

参加物

4

反応物 1

HCID 54775328Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate

生成物 1

HCID 54775640Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate収率 96.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate (2.2 g) and 10% Pd—C (0.60 g) in MeOH (30 mL) was hydrogenated under balloon pressure at room temperature overnight. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (1.8 g).

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-0bafab80cc2d4d5489845deb549d1470
出典データセット
uspto-grants-2015_05
特許番号
US09029536B2

反応ノート

読み込み中…