7-Chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine → HCID 66727973、化合物

HRID 573346ノート

反応式

HRID 573346 の反応式
Cl[C:2]1[C:3]2[N:10]([CH2:11][CH3:12])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1>CCOC(C)=O.[Pd]>[CH2:11]([N:10]1[C:3]2[CH:2]=[N:7][CH:6]=[N:5][C:4]=2[CH:8]=[N:9]1)[CH3:12]

参加物

4

反応物 1

HCID 714458087-Chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine

生成物 1

HCID 66727973HCID 66727973、化合物収率 93.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 7-chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine (105 mg), TEA (0.088 mL) and 10% Pd—C (30 mg) in AcOEt (5 mL) was hydrogenated under balloon pressure at room temperature for 2 h. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (80 mg).

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-82466f85a4994758adcb1ded58cd0c9f
出典データセット
uspto-grants-2015_05
特許番号
US09029536B2

反応ノート

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