関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2,2-Difluoroethyl trifluoromethanesulfonate | HCID 2774089 | — |
| 反応物 | HCID 178503348 | HCID 178503348 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(2,2-Difluoroethyl)-2-(methylsulfanyl)-3H-imidazo[4,5-b]pyridine | HCID 66727811 | 48% |
反応手順
A mixture of 2-(methylsulfanyl)-3H-imidazo[4,5-b]pyridine (600 mg) and 2,2-difluoroethyl trifluoromethanesulfonate (816 mg) in DMF (7 mL) was stirred at 80° C. for 3 h, treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure to give the title compound (400 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09029536B2 |
|---|
| 出典データセット | uspto-grants-2015_05 |
|---|
| ORD ID | ord-2d9016d9496f45a1ab6f94d4a0165361 |
|---|
| 出典メモ | uspto-grants-2015_05 |
|---|
