Hydrochloric Acid → 4-(4-trifluoromethoxyphenyl)benzylamine Hydrochloride

HRID 573476ノート

反応式

HRID 573476 の反応式
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.FC(F)(F)OC1C=CC(B(O)O)=CC=1.[ClH:34]>C(O)C.[OH-].[OH-].[Pd+2]>[ClH:34].[F:1][C:2]([F:18])([F:19])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][NH2:17])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 214636134-[4-(Trifluoromethoxy)phenyl]benzonitrile

生成物 1

HCID 229284574-(4-trifluoromethoxyphenyl)benzylamine Hydrochloride

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

A solution of 4′-[(trifluoromethyl)oxy]-4-biphenylcarbonitrile (prepared from {4-[(trifluoromethyl)oxy]phenyl}boronic acid by a method analogous to that described for the 4′-trifluoromethyl analogue, Intermediate D6 of WO 02/30911) (66.6 g) in ethanol (2000 ml) and concentrated hydrochloric acid (100 ml) was hydrogenated over Pearlman's catalyst (10 g) at 25 psi until reduction was complete. The catalyst was removed by filtration through celite, then the solvent was removed in vacuo to obtain the desired product.

後処理

  1. customThe catalyst was removed by filtration through celite
  2. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-0816bb231dc14f8b8ae5b70a7eb8f4a2
出典データセット
uspto-grants-2015_05
特許番号
US09029383B2

反応ノート

読み込み中…