4-tert-Butylcyclohexanone → 1-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

HRID 574135

反応式

HRID 574135 の反応式
[C:1]([CH:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[C:1]([CH:5]1[CH2:10][CH2:9][C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 73924-tert-ButylcyclohexanoneHCID 31268Pyrrolidine

生成物 1

HCID 1072321-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A 50 mL round-bottomed flask containing 4-tert-butylcyclohexanone (6.01 gm) in anhydrous toluene (20 mL) was fitted with a Dean-Stark trap containing 3 A molecular sieves, reflux condenser and a heating mantle. Pyrrolidine (6.00 mL) was added, and the solution heated to reflux for 18 hr. The solvent was evaporated and the crude product was used directly for the next reaction.

後処理

  1. customwas fitted with a Dean-Stark trap
  2. additioncontaining 3 A molecular sieves
  3. temperaturereflux condenser
  4. temperaturethe solution heated
  5. temperatureto reflux for 18 hr
  6. customThe solvent was evaporated
  7. customthe crude product was used directly for the next reaction

出典と根拠

ORDレコード
ord-1dfc076b8c0246ffa08371707ff08b15
出典データセット
uspto-grants-2015_05
特許番号
US09034871B2

関連ノート

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