Hydrochloric Acid → Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride

HRID 574151

反応式

C(OC([NH:8][CH:9]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[CH:22]=1)[C:10]([NH:12][C:13]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:15][CH2:14]1)=[O:11])=O)(C)(C)C.[ClH:31]>ClCCl.O1CCOCC1>[ClH:31].[NH2:8][CH:9]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:28])([F:29])[F:30])[CH:22]=1)[C:10]([NH:12][C:13]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:14][CH2:15]1)=[O:11]

参加物

実験手順

262 mg (0.61 mmol) of the compound of Example 17A were dissolved in 4 ml of dichloromethane, and 4 ml of a 4N solution of hydrogen chloride in dioxane were added. The solution was stirred at RT for 3 h and then freed from the volatile components on a rotary evaporator. The residue was dried under high vacuum. This gave 223 mg (quant.) of the title compound.

後処理

customfreed from the volatile components on a rotary evaporator
customThe residue was dried under high vacuum

出典と根拠

ORDレコード: ord-63ef24af7ed74888b706354e023f6057
出典データセット: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09034855B2

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

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