Hydrochloric Acid → 3-Amino-5,6-bis(trifluoromethyl)pyrazine-2-carbohydrazide

HRID 574241ノート

反応式

HRID 574241 の反応式
[NH2:1][C:2]1[C:3]([C:16](OCC)=[O:17])=[N:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.O.[NH2:22][NH2:23].Cl>CO.O>[NH2:1][C:2]1[C:3]([C:16]([NH:22][NH2:23])=[O:17])=[N:4][C:5]([C:12]([F:14])([F:15])[F:13])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 86657667Ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate

生成物 1

HCID 867296083-Amino-5,6-bis(trifluoromethyl)pyrazine-2-carbohydrazide

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A suspension of ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate (Int. G1)(455 mg, 1.501 mmol) in MeOH (10 ml) was treated with hydrazine monohydrate (0.147 ml, 3.00 mmol) and stirred at RT overnight. The reaction mixture was diluted with water (50 ml) and the pH was adjusted to pH4-5 using 1M HCl. A yellow precipitate formed which was filtered under vacuum, washed with water and air dried to afford the title compound which was used without further purification;

後処理

  1. customA yellow precipitate formed which
  2. filtrationwas filtered under vacuum
  3. washwashed with water and air
  4. customdried

出典と根拠

ORDレコード
ord-4b9721b5aba7433ebc7a754459f50caa
出典データセット
uspto-grants-2015_05
特許番号
US09034879B2

反応ノート

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