Chloroacetyl chloride → 2-Chloro-N-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-propyl-acetamide

HRID 574296

反応式

HRID 574296 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH:7]([NH:13][CH2:14][CH2:15][CH3:16])[CH2:8]2.C(N(CC)CC)C.[Cl:24][CH2:25][C:26](Cl)=[O:27]>>[Cl:24][CH2:25][C:26]([N:13]([CH:7]1[CH2:6][CH2:5][C:4]2[C:9](=[CH:10][CH:11]=[CH:12][C:3]=2[O:2][CH3:1])[CH2:8]1)[CH2:14][CH2:15][CH3:16])=[O:27]

参加物

4

反応物 3

HCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 102425482-Propylamino-5-methoxytetralin

生成物 1

HCID 675036922-Chloro-N-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-propyl-acetamide収率 93%

実験手順

This compound was prepared from 32b (4.63 g, 21.1 mmol), triethyl amine (5.1 ml, 42.2 mmol), and chloroacetyl chloride (1.80 ml, 25.4 mmol) by following Procedure B to give 33b (5.8 g, 93%). 1H NMR (400 MHz, CDCl3) 0.90-0.98 (m, 3H), 1.64-1.72 (m, 2H), 3.19-3.27 (m, 2H), 4.00 (s, 3H), 6.61-6.68 (m, 2H), 6.96-7.04 (m, 1H).

出典と根拠

ORDレコード
ord-52d4e3cc2c97418bac088f3b57b7a4cb
出典データセット
uspto-grants-2015_05
特許番号
US09034877B2

関連ノート

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