Hydrochloric Acid → HCID 178526812、化合物

HRID 574671

反応式

HRID 574671 の反応式
CN(C)[CH:3]=[C:4]([N+:10]([O-:12])=[O:11])[C:5](OCC)=[O:6].[CH2:14]([O:21][CH2:22][C:23](=[NH:25])[NH2:24])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.O(C)[Na].Cl>CO>[CH2:14]([O:21][CH2:22][C:23]1[N:24]=[C:5]([OH:6])[C:4]([N+:10]([O-:12])=[O:11])=[CH:3][N:25]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 4164062-PhenylmethoxyethanimidamideHCID 54330941ethyl 2-(N,N-dimethylaminomethylene)nitroacetate2 回HCID 178418582HCID 178418582、化合物

生成物 1

HCID 178526812HCID 178526812、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a mixture of step A product, 3-c, (24 g, 127 mmol) and 2-(benzyloxy)acetimidamide (25.9 g, 127 mmol) in CH3OH (30 mL) was added with NaOCH3 (14.2 g, 254 mmol) and 30° C. overnight. The pH of reaction mixture was adjusted to 7 by addition of concentrated HCl. The solids were filtered to afford the crude product, 3-d, (25 g). LC-MS (M+H)+ 262.1

後処理

  1. customThe pH of reaction mixture
  2. filtrationThe solids were filtered

出典と根拠

ORDレコード
ord-1eabca45e50047359115534ed1968bc6
出典データセット
uspto-grants-2015_05
特許番号
US09034851B2

関連ノート

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