methyl 3-isothiocyanato-4-methylthiophene-2-carboxylate → HCID 178431853、化合物
反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[N:11]([C:14]1[C:18]([CH3:19])=[CH:17][S:16][C:15]=1[C:20](OC)=[O:21])=[C:12]=[S:13]>C1COCC1>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[C:20](=[O:21])[C:15]4[S:16][CH:17]=[C:18]([CH3:19])[C:14]=4[NH:11][C:12]3=[S:13])=[CH:9][C:4]=2[N:3]=[CH:2]1参加物
4
実験手順
1H-benzo[d]imidazol-5-amine (0.13 g, 0.98 mmol) and methyl 3-isothiocyanato-4-methylthiophene-2-carboxylate (0.21 g, 0.98 mmol) were dissolved in 10 mL of THF. The mixture was stirred by heating under reflux over night. The solvent was removed and the product was purified by means of semi-preparative HPLC.
後処理
- temperatureby heating
- temperatureunder reflux over night
- customThe solvent was removed
- customthe product was purified by means of semi-preparative HPLC
出典と根拠
- ORDレコード
- ord-ee12f5ef980c4ddd8587512812870033
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09034907B2
反応ノート
読み込み中…