Dimethylamine → 4-((N,N-Dimethylamino)methyl)phenylboronic acid pinacol ester

HRID 57518ノート

反応式

HRID 57518 の反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)=[CH:5][CH:4]=1.[NH:18]([CH3:20])[CH3:19]>C1COCC1>[CH3:19][N:18]([CH3:20])[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 37345062-(4-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

生成物 1

HCID 34604594-((N,N-Dimethylamino)methyl)phenylboronic acid pinacol ester

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 2-(4-(bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (200 mg, 0.673 mmol) and aqueous Me2NH (4 mL) in THF (10 mL) was stirred at room temperature overnight. It was then concentrated under reduced pressure to give the title compound. MS (m/z): 262 (M+H)+.

後処理

  1. concentrationIt was then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-acbd8a8c17224c1387a500bd99a71009
出典データセット
uspto-grants-2016_09
特許番号
US09434726B2

反応ノート

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