3-Aminophenol → 5-Hydroxy-2-(3-hydroxyphenyl)isoindoline-1,3-dione

HRID 5752

反応式

HRID 5752 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[OH:9][C:10]1[CH:11]=[C:12]([C:19](O)=[O:20])[C:13](=[CH:17][CH:18]=1)[C:14](O)=[O:15]>C(O)(=O)C>[OH:8][C:4]1[CH:3]=[C:2]([N:1]2[C:19](=[O:20])[C:12]3=[CH:11][C:10]([OH:9])=[CH:18][CH:17]=[C:13]3[C:14]2=[O:15])[CH:7]=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 115683-AminophenolHCID 118814-Hydroxyphthalic acid

生成物 1

HCID 197939845-Hydroxy-2-(3-hydroxyphenyl)isoindoline-1,3-dione収率 80.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

m-Aminophenol(13.23 g, 0.12 mol) and 4-hydroxyphthalic acid (16.98 g, 0.09 mol) are allowed to react in refluxing acetic acid as described above. The product (21.6 g, 91%), collected as a tan solid, is recrystallized from methanol to give 18.5 g of pale yellow powder [mp 270° C. differential scanning calorimetry] having the following structure: ##STR7##

後処理

  1. customto react
  2. customThe product (21.6 g, 91%), collected as a tan solid
  3. customis recrystallized from methanol

出典と根拠

ORDレコード
ord-bae6517f0d0c4e2b88dc16d1d8fd4fb6
出典データセット
uspto-grants-1993_09
特許番号
US05246751

関連ノート

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