Cesium carbonate → (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-3-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

反応式

Br[C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[C:12]([CH2:16]Cl)=[C:13](I)[N:14]=[C:7]3[C:6]=2[CH:18]=1.[CH3:19][C:20]1[NH:24][C:23]2[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=2[N:21]=1.[C:29]([O-:32])([O-])=O.[Cs+].[Cs+].BrC1C=CC2OCC[N:42]3C(CN4C5C=CC=CC=5N=C4C)=C(I)N=C3C=2C=1.C[Si](N[Si](C)(C)C)(C)C.[CH3:71][C:72]1[O:76][N:75]=[C:74]([C@:77]([OH:81])([C:79]#[CH:80])[CH3:78])[CH:73]=1>CN(C)C=O.O.CS(C)=O.BrC1C=CC2OCCN3C(CN4C5C=CC=CC=5N=C4C)=C(C(N)=O)N=C3C=2C=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[OH:81][C@:77]([C:74]1[CH:73]=[C:72]([CH3:71])[O:76][N:75]=1)([CH3:78])[C:79]#[C:80][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[C:12]([CH2:16][N:21]4[C:22]5[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=5[N:24]=[C:20]4[CH3:19])=[C:13]([C:29]([NH2:42])=[O:32])[N:14]=[C:7]3[C:6]=2[CH:18]=1