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4,4-Difluorocyclohexan-1-amine hydrochloride → (R)-N3-(4,4-difluorocyclohexyl)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,4-Difluorocyclohexan-1-amine hydrochloride | HCID 23150669 | — |
| 反応物 | (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-(tetrahydro-2H-pyran-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide | HCID 86693302 | — |
| 生成物 | (R)-N3-(4,4-difluorocyclohexyl)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide | HCID 86693307 | — |
反応手順
Prepared as described for (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-(tetrahydro-2H-pyran-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide replacing 4-aminotetrahydropyran with 4-amino-1,1-difluorocyclohexane hydrochloride. Off-white solid 40.2 mg, 12%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09034866B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-839aee90a22248d68b2708fc93d14653 |
| 出典メモ | uspto-grants-2015_05 |