Dibenzylamine → 2-(3-(Dibenzylamino)-2-hydroxypropyl)isoindoline-1,3-dione

HRID 57595

反応式

HRID 57595 の反応式
[O:1]1[CH2:3][CH:2]1[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15].[CH2:16]([NH:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CCO>[CH2:24]([N:23]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:3][CH:2]([OH:1])[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

参加物

4

反応物 2

HCID 7656DibenzylamineHCID 21601N-(2,3-Epoxypropyl)phthalimide

生成物 1

HCID 104086942-(3-(Dibenzylamino)-2-hydroxypropyl)isoindoline-1,3-dione収率 56.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A mixture of 2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (4.06 g, 20.0 mmol) and dibenzylamine (5.0 g, 25.4 mmol) was stirred at 80° C. overnight. EtOH (50 mL) was added, and stirred at room temperature. The mixture was filtered to give white solid (4.5 g).

後処理

  1. stirringstirred at room temperature
  2. filtrationThe mixture was filtered

出典と根拠

ORDレコード
ord-b2a2f15a0b8848bb82600afc499c63de
出典データセット
uspto-grants-2016_09
特許番号
US09434726B2

関連ノート

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