4-methyl-8-nitro-2H-1,4-benzoxazin-3(4H)-one → 8-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one

HRID 576074ノート

反応式

HRID 576074 の反応式
[CH3:1][N:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([N+:12]([O-])=O)[C:6]=2[O:5][CH2:4][C:3]1=[O:15]>C(O)C.[Pd]>[NH2:12][C:11]1[C:6]2[O:5][CH2:4][C:3](=[O:15])[N:2]([CH3:1])[C:7]=2[CH:8]=[CH:9][CH:10]=1

参加物

4

反応物 1

HCID 389971764-methyl-8-nitro-2H-1,4-benzoxazin-3(4H)-one

生成物 1

HCID 263703078-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one収率 88.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 4-methyl-8-nitro-2 H-1,4-benzoxazin-3(4 H)-one (415 mg, 1.99 mmol) in ethanol (10 mL) was added 10% palladium activated carbon (415 mg) at room temperature, and the mixture was stirred overnight under a hydrogen atmosphere. The reaction mixture was filtered through Celite (registered trademark), followed by washing with ethanol. The filtrate was concentrated under reduced pressure. The resulting residue was dried under reduced pressure to afford the title compound as a gray powder (314 mg).

後処理

  1. filtrationThe reaction mixture was filtered through Celite (registered trademark)
  2. washby washing with ethanol
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customThe resulting residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-862f18eab74f4ad4bcf8f898dc1d921c
出典データセット
uspto-grants-2015_05
特許番号
US09035059B2

反応ノート

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