HCID 59163141、化合物 → tert-Butyl (3S)-3-acetylpyrrolidine-1-carboxylate
反応式
CON(C)[C:4]([C@H:6]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7]1)=[O:5].[CH3:19][Mg]Br>C1COCC1>[C:4]([C@H:6]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:12])[CH2:7]1)(=[O:5])[CH3:19]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of (S)-tert-butyl 3-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate in THF (18 mL) was added methylmagnesium bromide (in ether, 3 M, 2.7 mL) at 0° C. The mixture was stirred at 0° C. for 2 hours, then quenched with saturated aqueous NH4Cl, and extracted with Et2O. The combined extracts were washed with saturated aqueous NaHCO3, dried over Na2SO4, filtered, and concentrated to give the tile compound for the next step.
後処理
- customquenched with saturated aqueous NH4Cl
- extractionextracted with Et2O
- washThe combined extracts were washed with saturated aqueous NaHCO3
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- customto give the tile compound for the next step
出典と根拠
- ORDレコード
- ord-cf7fdb567c864b6a9533f641a5ca7db8
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434726B2
反応ノート
読み込み中…