Sodium borohydride → (S)-tert-butyl 3-(1-hydroxyethyl)pyrrolidine-1-carboxylate
反応式
[C:1]([C@H:4]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5]1)(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[OH:3][CH:1]([C@H:4]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:13])([CH3:15])[CH3:14])=[O:10])[CH2:5]1)[CH3:2]参加物
4
実験手順
To a solution of (S)-tert-butyl 3-acetylpyrrolidine-1-carboxylate in methanol (10 mL) was added sodium borohydride (114 mg, 3.0 mmol) at 0° C. The reaction mixture was stirred at ambient temperature for 2 hours then quenched with saturated ammonium chloride solution and extracted with dichloromethane. The combined extracts were dried over magnesium sulfate, filtered, and concentrated to give the title compound for the next step.
後処理
- customthen quenched with saturated ammonium chloride solution
- extractionextracted with dichloromethane
- dry with materialThe combined extracts were dried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-4fb5d22d6b59418ba567344c09e3fb35
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434726B2
反応ノート
読み込み中…