Water → HCID 10845513、化合物

HRID 576276ノート

反応式

HRID 576276 の反応式
C[Si](C)(C)[N-][Si](C)(C)C.[Li+].[Br:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]#[CH:19].[CH3:20]OS(OC)(=O)=O.O>O1CCCC1>[Br:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]#[C:19][CH3:20]

参加物

6

反応物 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 6020671-Bromo-2-ethynylbenzeneHCID 2733832Lithium Hexamethyldisilazide

生成物 1

HCID 10845513HCID 10845513、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1M Lithium hexamethyldisilazide solution (6 mL) was added to 1-bromo-2-ethynylbenzene (1 g) in 20 mL tetrahydrofuran at room temperature, and the reaction was stirred 30 minutes. (CH3)2SO4 (0.58 mL) was added and the reaction was stirred 30 minutes. The reaction was poured into 20 mL water, extracted with 2×50 mL ether, and the combined organic layers were dried over Na2SO4, filtered, and the filtrate was concentrated.

後処理

  1. stirringthe reaction was stirred 30 minutes
  2. extractionextracted with 2×50 mL ether
  3. dry with materialthe combined organic layers were dried over Na2SO4
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-b4e0c436c99f4c95aad5f5ead95384fe
出典データセット
uspto-grants-2015_05
特許番号
US09035047B2

反応ノート

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