N-Iodosuccinimide → HCID 68939125、化合物

HRID 576286ノート

反応式

HRID 576286 の反応式
[C:1]1([CH3:21])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:15]=1[NH:14][C:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12]2.[I:22]N1C(=O)CCC1=O>ClCCl>[I:22][C:12]1[C:11]2[C:15](=[C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=3[CH3:21])[CH:8]=[CH:9][CH:10]=2)[NH:14][C:13]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

参加物

4

反応物 2

HCID 120273N-IodosuccinimideHCID 68940392HCID 68940392、化合物

生成物 1

HCID 68939125HCID 68939125、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of EXAMPLE 564A (944 mg, 3.38 mmol) in dichloromethane (10 mL) was added 1-iodopyrrolidine-2,5-dione (798 mg, 3.55 9 mmol). The reaction mixture was stirred at room temperature for 3 hours and directly loaded on a flash column, eluting with hexane first and then with 0-50% hexane in dichloromethane. The title compound was obtained as a white solid.

後処理

  1. washeluting with hexane first

出典と根拠

ORDレコード
ord-dbc56471758842818f654fb5075d4aa1
出典データセット
uspto-grants-2015_05
特許番号
US09035047B2

反応ノート

読み込み中…