Dimethylformamide → 5-Bromo-2-chloro-3-methoxybenzoyl chloride
反応式
[Br:1][C:2]1[CH:3]=[C:4]([O:12][CH3:13])[C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].CN(C=O)C.C(Cl)(C([Cl:23])=O)=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([O:12][CH3:13])[C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7]([Cl:23])=[O:8]参加物
5
実験手順
To a solution of compound 56 (3.82 g, 14.3 mmol) in CH2Cl2 (63 mL) was added dropwise DMF (0.20 mL) and (COCl)2 (1.63 mL, 18.7 mmol) at 0° C. under an atmosphere of nitrogen. After being stirred for 20 hours at room temperature, the mixture was concentrated in vacuo to provide the crude acid chloride 59, which was used for the next reaction without further purification.
後処理
- concentrationthe mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-280873cd8a2c49c5b4742bcdb518c8ce
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09034921B2
反応ノート
読み込み中…