Acetyl chloride → HCID 53239786、化合物

HRID 576487ノート

反応式

HRID 576487 の反応式
[C:1]([NH:4][C@H:5]1[C@H:14]([C@@H:15]([C@@H:17]([CH2:19][OH:20])[OH:18])[OH:16])[O:13][C:8]([OH:12])([C:9](=[O:11])[OH:10])[CH2:7][C@@H:6]1[OH:21])(=[O:3])[CH3:2].[C:22](Cl)(=O)[CH3:23]>C(O)C>[C:1]([NH:4][C@H:5]1[C@H:14]([C@@H:15]([C@@H:17]([CH2:19][OH:20])[OH:18])[OH:16])[O:13][C:8]([OH:12])([C:9](=[O:10])[O:11][CH2:22][CH3:23])[CH2:7][C@@H:6]1[OH:21])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 439197N-Acetyl-Neuraminic Acid

生成物 1

HCID 53239786HCID 53239786、化合物収率 91.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of N-acetyl-neuraminic acid (1 g, 3.23 mmole) in anhydrous ethanol (75 ml) was added 1.5 ml acetyl chloride. The mixture was sealed and stirred at room temperature for 16 hrs. to form a clear solution. The resulting solution was vacuum evaporated to dryness. The white solid was washed with ethyl acetate and vacuum dried to afford the title compound as a white solid (1 g, 91.7%).

後処理

  1. customThe mixture was sealed
  2. customto form a clear solution
  3. customevaporated to dryness
  4. washThe white solid was washed with ethyl acetate and vacuum
  5. customdried

出典と根拠

ORDレコード
ord-7f9e2d549f6443b1a1bdd998a8751f4c
出典データセット
uspto-grants-2015_05
特許番号
US09040503B2

反応ノート

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