Sodium Iodide → 2-(3-(4-(5-Chloro-2-methylphenyl)piperazin-1-yl)propyl)isoindoline-1,3-dione

HRID 576505

反応式

HRID 576505 の反応式
Br[CH2:2][CH2:3][CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15].[Na+].[I-].[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([CH3:31])=[C:23]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:24]=1>CC(C)=O>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([CH3:31])=[C:23]([N:25]2[CH2:26][CH2:27][N:28]([CH2:2][CH2:3][CH2:4][N:5]3[C:13](=[O:14])[C:12]4[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=4)[C:6]3=[O:15])[CH2:29][CH2:30]2)[CH:24]=1

参加物

5

反応物 3

HCID 5238Sodium IodideHCID 21611N-3-BromopropylphthalimideHCID 693767N-(5-Chloro-2-methylphenyl)piperazine

生成物 1

HCID 585388742-(3-(4-(5-Chloro-2-methylphenyl)piperazin-1-yl)propyl)isoindoline-1,3-dione収率 81%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2-(3-bromopropyl)isoindoline-1,3-dione (2.68 g, 10 mmol) and NaI (20 mmol) in acetone was refluxed for 5 h, then to it was added 1-(5-chloro-2-methylphenyl)piperazine (2.11 g, 10.0 mmol). The reflux was continued for 12 h. Reaction was then cooled to room temperature, filtered through celite and concentrated. The crude product was recrystallized from acetone to give the title compound as a white solid (3.21 g, 81%).

後処理

  1. temperaturewas refluxed for 5 h
  2. customReaction
  3. filtrationfiltered through celite
  4. concentrationconcentrated
  5. customThe crude product was recrystallized from acetone

出典と根拠

ORDレコード
ord-23c411aacfc14b86ba59836a7cfc6d95
出典データセット
uspto-grants-2015_05
特許番号
US09040508B2

関連ノート

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