5-Cyano-1-[3-(trifluoromethyl)phenyl]uracil → HCID 86723841、化合物
反応式
[O:1]=[C:2]1[NH:7][C:6](=[O:8])[C:5](C#N)=[CH:4][N:3]1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1.O.N>Br>[F:20][C:17]([F:18])([F:19])[C:13]1[CH:12]=[C:11]([N:3]2[CH:4]=[CH:5][C:6](=[O:8])[NH:7][C:2]2=[O:1])[CH:16]=[CH:15][CH:14]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
2,4-Dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonitrile (prepared in Reference Example 112) (22.7 g) was suspended in hydrobromic acid (48%, 220 ml) and the resulting mixture was stirred with heating under reflux for ten hours. The resulting mixture was cooled to 0° C. and to the reaction solutions was then added 28% ammonia water (145 ml) dropwise, and the precipitated solids were collected by filtration and washed with water to afford 1-(3-(trifluoromethyl)phenyl)pyrimidin-2,4(1H,3H)-dione (17.8 g).