1,1'-Carbonyldiimidazole → 3-Chloro-9-cyclohexylimidazo[1,5-a]pyrido[3,2-e]pyrazin-6(5h)-one

HRID 576838ノート

反応式

HRID 576838 の反応式
[NH2:1][C:2]1[C:3]([N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[C:20](N1C=CN=C1)(N1C=CN=C1)=[O:21]>>[Cl:8][C:6]1[CH:5]=[N:4][C:3]2[N:9]3[C:10]([CH:14]4[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]4)=[N:11][CH:12]=[C:13]3[C:20](=[O:21])[NH:1][C:2]=2[CH:7]=1

参加物

3

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 59198835HCID 59198835、化合物

生成物 1

HCID 591985613-Chloro-9-cyclohexylimidazo[1,5-a]pyrido[3,2-e]pyrazin-6(5h)-one

実験手順

3-Amino-5-chloro-2-(2-cyclohexyl-1H-imidazol-1-yl)pyridine as synthesized in Production Example 103, 838 mg, 1,1′-carbonyldiimidazole 983 mg and 1,2-chlorobenzene 25 mL were mixed and heated under reflux for 15 hours. Cooling the reaction liquid off, the precipitate was recovered by filtration and washed with methanol. The resulting crystals were dissolved in a liquid mixture of 2N hydrochloric acid and methanol, and the insoluble matter was separated by filtration. The filtrate was made weakly alkaline with saturated aqueous sodium hydrogencarbonate solution, and the precipitate was recovered by filtration. Drying the same in flowing air under heating, 620 mg of the title compound was obtained.

後処理

  1. additionwere mixed
  2. temperatureheated
  3. temperatureunder reflux for 15 hours
  4. temperatureCooling
  5. customthe reaction liquid off, the precipitate
  6. filtrationwas recovered by filtration
  7. washwashed with methanol
  8. dissolutionThe resulting crystals were dissolved in a liquid mixture of 2N hydrochloric acid and methanol
  9. customthe insoluble matter was separated by filtration
  10. filtrationthe precipitate was recovered by filtration
  11. customDrying the same
  12. temperatureunder heating

出典と根拠

ORDレコード
ord-125fd5e21de64d53991e28bce0c0a558
出典データセット
uspto-grants-2015_05
特許番号
US09040536B2

反応ノート

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