Methylhydrazine → Ethyl 2-(1-methylhydrazinyl)acetate

To a solution of methylhydrazine 7.13 ml (150 mmol) and triethylamine 16.7 ml (120 mmol), ethyl 2-bromoacetate 16.7 g (100 mmol) in dichloromethane 50 ml was added and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate 300 ml and washed with brine 200 ml. The organic phase was dried over magnesium sulfate and filtered and the mother solution was concentrated in vacuo to obtain the title compound 10.2 g (77%).

1. washwashed with brine 200 ml
2. dry with materialThe organic phase was dried over magnesium sulfate
3. filtrationfiltered
4. concentrationthe mother solution was concentrated in vacuo

ORDレコード

ord-55b3a420a88f4d3b88cd052751607f87

出典データセット

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09040531B2