3-Quinolinecarboxaldehyde → (Quinolin-3-yl)methanol

HRID 576957

反応式

HRID 576957 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([CH:11]=[O:12])[CH:2]=1.[BH4-].[Na+]>C(O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([CH2:11][OH:12])[CH:2]=1

参加物

4

反応物 2

HCID 836413-QuinolinecarboxaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 12662983(Quinolin-3-yl)methanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
0 °C

実験手順

In a 250 mL round bottom flask, quinoline-3-carbaldehyde (1.57 g, 10 mmol) was dissolved anhydrous ethanol (20 mL). The solution was cooled to 0° C. under nitrogen. NaBH4 (420 mg, 11 mmol) was added in one portion. The mixture was stirred at room temperature for 2 hours, and quenched by addition of water (3 mL). Na2SO4 (15 g) was added. After 10 minutes, the mixture was filtered. The filtrate was evaporated to provide quinolin-3-ylmethanol.

後処理

  1. customquenched by addition of water (3 mL)
  2. additionNa2SO4 (15 g) was added
  3. waitAfter 10 minutes
  4. filtrationthe mixture was filtered
  5. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-5cb8498e4d874eee874d8ceafcc87088
出典データセット
uspto-grants-2015_05
特許番号
US09040538B2

関連ノート

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