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Phosphorus tribromide → 3-(Bromomethyl)quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus tribromide | HCID 24614 | — |
| 反応物 | (Quinolin-3-yl)methanol | HCID 12662983 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(Bromomethyl)quinoline | HCID 23510331 | — |
反応手順
Quinolin-3-ylmethanol was dissolved dichloromethane (15 mL) at 0° C. under nitrogen. Tribromophosphane (2.15 mL, 22 mmol) was added dropwise. The resulting mixture was stirred at room temperature overnight. The reaction was quenched by addition of 10% NaHCO3 solution (5 mL). After 10 minutes, Na2SO4 (30 g) was added. The solvent was filtered and evaporated to provide 3-(bromomethyl)quinoline, which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09040538B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-bf1bb2d7b0d3480a847ced8e57081458 |
| 出典メモ | uspto-grants-2015_05 |