Formaldehyde → (3-chloro-2H-indazol-2-yl)methanol

HRID 576978

反応式

HRID 576978 の反応式
[Cl:1][C:2]1[NH:3][N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.[CH2:11]=[O:12]>O>[Cl:1][C:2]1[N:3]([CH2:11][OH:12])[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2

参加物

4

反応物 2

HCID 712FormaldehydeHCID 958943-Chloro-1H-indazole

生成物 1

HCID 59589510(3-chloro-2H-indazol-2-yl)methanol収率 99.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a 250 mL round bottom flask, 3-chloro-2H-indazole (1.95 g, 10 mmol), 30% HCHO (2 mL, 20 mmol) were mixed in water (10 mL). The reaction mixture was refluxed for 2 hours. After cooling down to room temperature, the solid was filtered, washed with water, and dried under vacuum to provide (3-chloro-2H-indazol-2-yl)methanol (1.82 g, 99% yield).

後処理

  1. temperatureThe reaction mixture was refluxed for 2 hours
  2. filtrationthe solid was filtered
  3. washwashed with water
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-e9343ec9cd194c3787ce60170fb37abe
出典データセット
uspto-grants-2015_05
特許番号
US09040538B2

関連ノート

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