Water → (Dichloro-1,3-thiazol-5-yl)methanol

HRID 577004ノート

反応式

HRID 577004 の反応式
[Cl:1][C:2]1[S:3][C:4]([CH:8]=[O:9])=[C:5]([Cl:7])[N:6]=1.[BH4-].[Na+].O>CO>[Cl:1][C:2]1[S:3][C:4]([CH2:8][OH:9])=[C:5]([Cl:7])[N:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 14886722,4-Dichloro-1,3-thiazole-5-carboxaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 10375112(Dichloro-1,3-thiazol-5-yl)methanol収率 84%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a 0° C. solution of 2,4-dichloro-1,3-thiazole-5-carbaldehyde (1.0 g, 5.5 mmol) in anhydrous methanol (45 mL) was added sodium borohydride (340 mg, 9.0 mmol). The reaction mixture was stirred at room temperature overnight. Water (50 mL) was added and the methanol was evaporated. The resultant mixture was extracted with EtOAc (2×50 mL). The organic extracts were combined, dried over MgSO4, filtered, evaporated, and dried in vacuo, to afford (2,4-dichloro-1,3-thiazol-5-yl)methanol (850 mg, 84% yield). The product was used without further purification.

後処理

  1. customthe methanol was evaporated
  2. extractionThe resultant mixture was extracted with EtOAc (2×50 mL)
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customevaporated
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-005db0203bd84bbe9e9d7ccd6442e717
出典データセット
uspto-grants-2015_05
特許番号
US09040538B2

反応ノート

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