Thionyl Chloride → 5-chloro-4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride

HRID 577070ノート

反応式

HRID 577070 の反応式
[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[CH2:8]O.S(Cl)([Cl:12])=O>ClCCl>[ClH:1].[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[CH2:8][Cl:12]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 21657108(5-chloro-1-methyl-1H-imidazol-4-yl)methanol

生成物 1

HCID 668208135-chloro-4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride収率 99%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (5-chloro-1-methyl-1H-imidazol-4-yl)methanol (397 mg, 2.7 mmol) in anhydrous dichloromethane (20 mL) was added thionyl chloride (1 mL). The mixture was stirred at room temperature for 2 hours. Dichloromethane was evaporated and then co-evaporated with toluene (2×10 mL). The residue was dried in vacuo, affording 5-chloro-4-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (550 mg, 99% yield). The product was used without further purification.

後処理

  1. customDichloromethane was evaporated
  2. customThe residue was dried in vacuo

出典と根拠

ORDレコード
ord-2d828c42de964eba8b8f934d95d1aaf5
出典データセット
uspto-grants-2015_05
特許番号
US09040538B2

反応ノート

読み込み中…