tert-butyl 4-nitro-1H-pyrazole-1-carboxylate → tert-butyl 4-amino-1H-pyrazole-1-carboxylate
反応式
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:8]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:8]=1参加物
4
実験手順
tert-butyl 4-nitro-1H-pyrazole-1-carboxylate was stirred with palladium on carbon (10%, 170 mg) in ethanol (20 mL) under an atmosphere of hydrogen at 20° C. for 18 h. The palladium was removed by filtration and the solvent was removed in vacuo to give tert-butyl 4-amino-1H-pyrazole-1-carboxylate (1.48 g). 1H NMR (d6-DMSO) δ 7.35 (d, 1H), 7.33 (d, 1H), 4.40 (s, 2H), 1.54 (s, 9H).
後処理
- customThe palladium was removed by filtration
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-04f9edca0c134f42a0c0f9eff08eb84a
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09040545B2
反応ノート
読み込み中…