6-fluoro-7-methoxyisoquinolin-1(2H)-one → 6-fluoro-7-methoxy-3,4-dihydroisoquinolin-1(2H)-one
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[NH:7][CH:6]=[CH:5]2>CCO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[NH:7][CH2:6][CH2:5]2参加物
4
実験手順
A suspension of 6-fluoro-7-methoxyisoquinolin-1(2H)-one (Cpd L, 0.531 g, 2.75 mmol) and 10% Pd/C in EtOH (20 mL) was stirred vigorously under a blanket of H2 (balloon) at room temperature for 2 days. The reaction mixture was filtered and the filtrate was concentrated under vacuum to give 6-fluoro-7-methoxy-3,4-dihydroisoquinolin-1(2H)-one (Cpd M, 430 mg, 80%) as a white powder.
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-38861fb43cf9460d896b1af021220119
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09040515B2
反応ノート
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