Benzyl-(6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl)-amine → 6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-amine
反応式
C([NH:8][CH:9]1[CH2:15][CH2:14][C:13]2[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=2[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[CH:16]1[C:13]2[CH2:14][CH2:15][CH:9]([NH2:8])[CH2:10][CH2:11][C:12]=2[CH:19]=[CH:18][CH:17]=1参加物
4
実験手順
Benzyl-(6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl)-amine (2.80 g) is dissolved in methanol (100 mL) and the composed is deprotected by adding a catalytic amount of 10% palladium on charcoal and placing the solution under an atmosphere of hydrogen. The reaction is shown to be complete by TLC after 24 hours. The catalyst is filtered off and the solvent is removed in vacuo. The product is not purified further. TLC (silica, dichloromethane/methanol 25:1 Rf=0.15).
後処理
- filtrationThe catalyst is filtered off
- customthe solvent is removed in vacuo
- customThe product is not purified further
出典と根拠
- ORDレコード
- ord-5eb0cf58d62d4a1183bede2a5f72e8a6
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09040559B2
反応ノート
読み込み中…