Acetyl chloride → HCID 68750450、化合物
反応式
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:16][CH:17]([F:19])[F:18])=[C:10]([CH:15]=1)[C:11]([O:13][CH3:14])=[O:12]>C1COCC1>[C:1]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([O:16][CH:17]([F:18])[F:19])=[C:10]([CH:15]=1)[C:11]([O:13][CH3:14])=[O:12])(=[O:3])[CH3:2]参加物
4
実験手順
Acetylchloride (1.8 mL, 25.3 mmol) in 25 mL THF was added to a mixture of methyl 5-amino-2-difluoromethoxy-benzoate (5.40 g, 24.9 mmol) with TEA (4.5 mL, 32.4 mmol) in 50 mL THF and the resulting mixture stirred for 15 min at ambient temperature. The mixture was filtered and the filtrate concentrated i. vac. The residue was mixed with acetonitrile and water, concentrated i. vac. and the solid filtered off. It was washed with water and dried at 40° C.
後処理
- filtrationThe mixture was filtered
- concentrationthe filtrate concentrated i
- additionThe residue was mixed with acetonitrile and water
- concentrationconcentrated i
- filtrationand the solid filtered off
- washIt was washed with water
- customdried at 40° C.
出典と根拠
- ORDレコード
- ord-81c13605128a4902bf26b9d78d10fd41
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09040565B2
反応ノート
読み込み中…