Diethyl Ether → 2-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-4-methyl-thiazole-5-carboxylic acid

HRID 579440ノート

反応式

HRID 579440 の反応式
C([O:5][C:6]([C:8]1[S:12][C:11]([C:13]2[C:14](=[O:24])[O:15][C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[C:18]([OH:23])[CH:17]=3)=[N:10][C:9]=1[CH3:25])=[O:7])(C)(C)C.C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O.C(OCC)C>ClCCl>[OH:23][C:18]1[CH:17]=[C:16]2[C:21]([CH:22]=[C:13]([C:11]3[S:12][C:8]([C:6]([OH:7])=[O:5])=[C:9]([CH3:25])[N:10]=3)[C:14](=[O:24])[O:15]2)=[CH:20][CH:19]=1

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 1363877692-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-4-methyl-thiazole-5-carboxylic acid tert-butyl ester

生成物 1

HCID 1363877702-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-4-methyl-thiazole-5-carboxylic acid収率 87%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a suspension of 2-(7-hydroxy-2-oxo-2H-chromen-3-yl)-4-methyl-thiazole-5-carboxylic acid tert-butyl ester (387 mg, 1.08 mmol) and anisole (117 μL, 117 mg, 1.08 mmol) in anhydrous dichloromethane (5 mL) was added trifluoroacetic acid (5 mL) and the obtained solution was stirred at room temperature for 6 h. Diethyl ether (30 mL) was added, the precipitate was collected, washed with diethyl ether and dried in air. In this manner the title compound (285 mg, 0.94 mmol, 87%) was obtained as a light brown solid.

後処理

  1. customthe precipitate was collected
  2. washwashed with diethyl ether
  3. customdried in air

出典と根拠

ORDレコード
ord-92a337548f80445897935269cabf3ad4
出典データセット
uspto-grants-2015_05
特許番号
US09040714B2

反応ノート

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