N-bromobutanimide → 2-Bromo-1-morpholin-4-yl-butane-1,3-dione
反応式
[N:1]1([C:7](=[O:12])[CH2:8][C:9](=[O:11])[CH3:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Br:13]N1C(=O)CCC1=O>ClCCCl>[Br:13][CH:8]([C:9](=[O:11])[CH3:10])[C:7]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)=[O:12]参加物
4
実験手順
To a solution of 1-morpholin-4-yl-butane-1,3-dione (0.53 g, 3.1 mmol) in 1,2-dichloroethane (30 mL) stirred at 0° C., N-bromosuccinimide (0.55 mg, 3.1 mmol) was added in small portions and the mixture was stirred for 1 h. The solution was washed with brine (3×5 mL), dried over MgSO4 and concentrated below 30° C. 2-Bromo-1-morpholin-4-yl-butane-1,3-dione 0.76 g, 3.04 mmol, 98.1%, LCMS/BB_LCMS01(+)/: M+1=250, 252, Rt: 1.831 min] was obtained as a yellowish oil.
後処理
- washThe solution was washed with brine (3×5 mL)
- dry with materialdried over MgSO4
- concentrationconcentrated below 30° C
出典と根拠
- ORDレコード
- ord-c3e4f7c87be047c9b1b06ebcd0d0c235
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09040714B2
反応ノート
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