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Pyridine → 6-Hydroxy-2-oxo-1,2-dihydroquinoline-5-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Trifluoroacetic anhydride | HCID 9845 | — |
| 反応物 | 3-Bromo-7-hydroxy-4-methylchromen-2-one | HCID 5337545 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-Hydroxy-2-oxo-1,2-dihydroquinoline-5-carbaldehyde | HCID 86683429 | 95.3% |
反応手順
Compound 1 (38 g, 249.6 mmol) and pyridine (21.7 g, 275.0 mmol) were dissolved in DCM (750 mL). (CF3CO)2O (57.7 g, 275.0 mmol) was added dropwise at 0° C. After that the reaction mixture was stirred at RT for 16 h. The reaction mixture was diluted with DCM (500 mL), washed with 1N HCl, concentrated. The residue was purified by silica gel column (PE:EA=10:1), afforded compound 2 (45 g, 72%) as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09040714B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-e66b7c0178974a83b40a588fcf4809cb |
| 出典メモ | uspto-grants-2015_05 |