Diisopropylethylamine → 1-(3-Bromo-6-iodopyridin-2-yl)-1,4-diazepan-6-ol

HRID 57977ノート

反応式

HRID 57977 の反応式
[Br:1][C:2]1[C:3](F)=[N:4][C:5]([I:8])=[CH:6][CH:7]=1.[NH:10]1[CH2:16][CH:15]([OH:17])[CH2:14][NH:13][CH2:12][CH2:11]1.CCN(C(C)C)C(C)C>CCO>[Br:1][C:2]1[C:3]([N:10]2[CH2:16][CH:15]([OH:17])[CH2:14][NH:13][CH2:12][CH2:11]2)=[N:4][C:5]([I:8])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 211142751,4-Diazepan-6-olHCID 717430873-Bromo-2-fluoro-6-iodopyridine

生成物 1

HCID 867071591-(3-Bromo-6-iodopyridin-2-yl)-1,4-diazepan-6-ol収率 87.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3-bromo-2-fluoro-6-iodopyridine (1.00 g, 3.4 mmol), 1,4-diazepan-6-ol (510 mg, 4.4 mmol), and DIPEA (2 mL) in EtOH (6 mL) in a sealed tube was stirred at 100° C. for 20 hours. The reaction mixture was concentrated under reduced pressure to give a residue (1.18 g), which was used for the next step without further purification. MS (ESI) m/z: 398 [M+H]+.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-430b14e236a94fdb91f5f889ce24ada9
出典データセット
uspto-grants-2016_09
特許番号
US09434725B2

反応ノート

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