Methanol → AC-Pro-ome

HRID 579825

反応式

HRID 579825 の反応式
C[OH:2].[C:3]([N:6]1[CH2:10][CH2:9][CH:8]=[CH:7]1)(=[O:5])[CH3:4].[O:11]1[CH2:15]CC[CH2:12]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:12][O:11][C:15](=[O:2])[C@@H:7]1[CH2:8][CH2:9][CH2:10][N:6]1[C:3](=[O:5])[CH3:4]

参加物

5

反応物 3

HCID 887MethanolHCID 8028TetrahydrofuranHCID 10909522N-Acetyl-2-pyrroline2 回

生成物 1

HCID 11019314AC-Pro-ome収率 42.8%

試薬・触媒・溶媒 1

HCID 178418476HCID 178418476、化合物触媒

反応条件

温度
100 °C

実験手順

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pendadecane internal standard, 0.5 mmol of CH3OH, 35.1 mg of (PPh3)2PdCl2, and 56.6 mg of N-acetyl-2-pyrroline. The reactor was pressurized to 1000 psi with CO at room temperature, and the reaction mixture was stirred at 100° C. for 26 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 98.4% conversion of N-acetyl-2-pyrroline and 42.8% yield of N-acetylproline methyl ester.

後処理

  1. customA 70 mL stainless steel high pressure reactor having
  2. customwas pressurized to 1000 psi with CO at room temperature
  3. temperatureThereafter, the reactor was cooled to room temperature

出典と根拠

ORDレコード
ord-23c5847cc75b4d75b1676b3af4447543
出典データセット
uspto-grants-1988_06
特許番号
US04749786

関連ノート

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