Methanol → AC-Pro-ome

HRID 579828

反応式

HRID 579828 の反応式
CCCCCCCCCCCCCCC.C[OH:17].[C:18]([N:21]1[CH2:25][CH2:24][CH:23]=[CH:22]1)(=[O:20])[CH3:19].[O:26]1[CH2:30]CC[CH2:27]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:27][O:26][C:30](=[O:17])[C@@H:22]1[CH2:23][CH2:24][CH2:25][N:21]1[C:18](=[O:20])[CH3:19]

参加物

6

反応物 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 12391PentadecaneHCID 10909522N-Acetyl-2-pyrroline2 回

生成物 1

HCID 11019314AC-Pro-ome収率 25.2%

試薬・触媒・溶媒 1

HCID 178418476HCID 178418476、化合物触媒

反応条件

温度
100 °C

実験手順

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pentadecane internal standard, 0.75 mmol of CH3OH, 56.8 mg of (PPh3)2PdCl2, and 72.35 mg of N-acetyl-2-pyrroline. The reactor was pressurized with 1000 psi of CO and 300 psi of H2 at room temperature, and the reaction mixture was stirred at 100° C. for 18 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 100% conversion of N-acetyl-2-pyrroline and 25.2% yield of N-acetylproline methyl ester.

後処理

  1. customA 70 mL stainless steel high pressure reactor having
  2. customwas pressurized with 1000 psi of CO and 300 psi of H2 at room temperature
  3. temperatureThereafter, the reactor was cooled to room temperature

出典と根拠

ORDレコード
ord-393971dd9a944e91b90cd4b696449cac
出典データセット
uspto-grants-1988_06
特許番号
US04749786

関連ノート

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