Sodium Hydroxide → Benzyl(2-methylpropyl)amine

HRID 579839ノート

反応式

HRID 579839 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH:7](=[N:14][CH2:15][CH:16]([CH3:18])[CH3:17])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Na+]>CCOCC>[CH3:17][CH:16]([CH3:18])[CH2:15][NH:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 118050671-Propanamine, 2-methyl-N-(phenylmethylene)-HCID 21226445Aluminium lithium hydride

生成物 1

HCID 211729Benzyl(2-methylpropyl)amine収率 90.6%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a stirred solution of lithium aluminum hydride (23 g, 606 mmol) in ether (115 ml) was added an ethereal solution (115 ml) of N-benzylidene-2-methyl-1-propanamine (72.1 g, 447 mmol) over a period of 45 minutes. It was then refluxed for one hour. The reaction mixture was cooled in an ice bath and while stirring vigorously, aqueous sodium hydroxide (20%, 120 ml) was added dropwise. The ether solution was separated, dried over magnesium sulfate and concentrated to dryness yielding 66.1 g of the title compound.

後処理

  1. temperatureIt was then refluxed for one hour
  2. temperatureThe reaction mixture was cooled in an ice bath
  3. customThe ether solution was separated
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-67f93610a6b642f4894926ad22ab25d9
出典データセット
uspto-grants-1988_06
特許番号
US04749792

反応ノート

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