Hydrochloric Acid → 4-Methyl-2-(trifluoromethyl)aniline

HRID 579857ノート

反応式

HRID 579857 の反応式
Cl.O1CCOCC1.[N+:8]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:12]=1[C:18]([F:21])([F:20])[F:19])([O-])=O>O.[Fe]>[F:19][C:18]([F:20])([F:21])[C:12]1[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:11]=1[NH2:8]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 134554324-Methyl-1-nitro-2-(trifluoromethyl)benzene

生成物 1

HCID 27377104-Methyl-2-(trifluoromethyl)aniline収率 86.3%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 962Water溶媒

実験手順

100 g of iron fillings are heated to 95° C. in 300 ml of water, 5 ml of hydrochloric acid and 5 ml of dioxane in a stirred vessel, and 57 g of 2-nitro-5-methylbenzotrifluoride are added dropwise in the course of about 1 hour. The mixture is stirred for a further 2 hours, and a distillation is then carried out using steam. The organic material extracted with dichloromethane and re-distilled. 42 g (boiling point: 92°-95° C./20 mbar) of 2-trifluoromethyl-4-methylaniline are obtained.

後処理

  1. distillationa distillation
  2. extractionThe organic material extracted with dichloromethane
  3. distillationre-distilled

出典と根拠

ORDレコード
ord-803b3e8da6c14466a4316cba997ef9ae
出典データセット
uspto-grants-1988_06
特許番号
US04749813

反応ノート

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