Hydrochloric Acid → (4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%

HRID 579904ノート

反応式

HRID 579904 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH:13]NC(=O)C2C=CC=CC=2)=[S:12])[N:4]=1.[OH-].[Na+].Cl>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH2:13])=[S:12])[N:4]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54321636HCID 54321636、化合物

生成物 1

HCID 939981(4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%収率 102.5%

実験手順

A mixture of 25 g of the compound from Example 3 and 55 ml of 10% aqueous sodium hydroxide was heated on the steam bath for 30 minutes, cooled, neutralized with aqueous HCl to pH 8, filtered, washed with water, dried by suction, and washed with ether to afford 16 g of the title compound, m.p. 220° d.

後処理

  1. temperaturewas heated on the steam bath for 30 minutes
  2. temperaturecooled
  3. filtrationfiltered
  4. washwashed with water
  5. customdried by suction
  6. washwashed with ether

出典と根拠

ORDレコード
ord-c13829d1f13f45e4bd71f23e498d6250
出典データセット
uspto-grants-1988_06
特許番号
US04750930

反応ノート

読み込み中…