Water → 2,3-Quinolinedicarboxylic acid

HRID 579910

反応式

HRID 579910 の反応式
Cl.[CH3:2][C:3]1[C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[OH-:16].[Na+].ClCl.[OH2:20]>>[N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:12]([C:13]([OH:15])=[O:14])[C:3]=1[C:2]([OH:20])=[O:16]

参加物

5

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 24526ChlorineHCID 163193672-Methylquinoline-3-carboxylic acid hydrochloride

生成物 1

HCID 695082,3-Quinolinedicarboxylic acid

反応条件

温度
85 °C

実験手順

To a reactor is added 4.03 g (18.9 mmol) of 2-methyl-3-quinolinecarboxylic acid hydrochloride and 40 ml water. The pH is adjusted to pH 10 and 16.0 g cupric hydroxide is added. The solution is warmed to 85° C. for 60 minutes; then cooled and held at 55° C. A pH controller is set to maintain the pH above 10 by the incremental addition of aqueous 50% sodium hydroxide solution. Chlorine gas is introduced at approximately 1 g/hr to give a total of 20 g after 21 hours. The reaction mixture is filtered and analyzed; 2.82 g of 2,3-quinolinedicarboxylic acid is obtained. The reaction is illustrated as follows: ##STR6##

後処理

  1. additionis added
  2. temperaturethen cooled
  3. customheld at 55° C
  4. temperatureto maintain the pH above 10
  5. customto give a total of 20 g after 21 hours
  6. filtrationThe reaction mixture is filtered

出典と根拠

ORDレコード
ord-6bc0b420f6f44222b8bd604944ee7caa
出典データセット
uspto-grants-1988_06
特許番号
US04750978

関連ノート

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