Chlorine → 1-(2-Fluoro-4-chloro-5-methylsulfonyloxyphenyl)-3,5-dimethyl-4-chloropyrazole

HRID 580266ノート

反応式

HRID 580266 の反応式
[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][S:10]([CH3:13])(=[O:12])=[O:11])=[CH:4][C:3]=1[N:14]1[C:18]([CH3:19])=[CH:17][C:16]([CH3:20])=[N:15]1.[Cl:21]Cl>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][S:10]([CH3:13])(=[O:12])=[O:11])=[CH:4][C:3]=1[N:14]1[C:18]([CH3:19])=[C:17]([Cl:21])[C:16]([CH3:20])=[N:15]1

参加物

4

反応物 2

HCID 24526ChlorineHCID 137982511-(2-Fluoro-4-chloro-5-methylsulfonyloxyphenyl)-3,5-dimethylpyrazole

生成物 1

HCID 137983221-(2-Fluoro-4-chloro-5-methylsulfonyloxyphenyl)-3,5-dimethyl-4-chloropyrazole収率 99.6%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Into a solution of 1-(2-fluoro-4-chloro-5-methylsulfonyloxyphenyl)-3,5-dimethylpyrazole (31.9 g) in chloroform (200 ml) was introduced chlorine gas (7.1 g) for 10 minutes under water-cooling, and then the reaction mixture was stirred for further 30 minutes to effect the chlorination reaction. Removal of the solvent from the reaction solution by distillation in vacuo gave the titled compound (35.2 g) as a pale brown oil. Purification of this oil by silica gel column chromatography yielded a colorless oil. nD23 =1.5431.

後処理

  1. temperaturecooling
  2. customthe chlorination reaction
  3. customRemoval of the solvent from the reaction solution
  4. distillationby distillation in vacuo

出典と根拠

ORDレコード
ord-094d6ea7a4884f658cd8493920541ee8
出典データセット
uspto-grants-1988_06
特許番号
US04752326

反応ノート

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