Water → Sodium oleanolate

HRID 580310ノート

反応式

HRID 580310 の反応式
[OH-].[Na+:2].[CH3:3][C@@:4]12[C@H:13]3[CH2:14][CH:15]=[C:16]4[C@@H:21]5[CH2:22][C:23]([CH3:27])([CH3:26])[CH2:24][CH2:25][C@:20]5([C:28]([OH:30])=[O:29])[CH2:19][CH2:18][C@@:17]4([CH3:31])[C@:12]3([CH3:32])[CH2:11][CH2:10][C@H:9]1[C:8]([CH3:34])([CH3:33])[C@@H:7]([OH:35])[CH2:6][CH2:5]2.O.ClCCl>C(OCC)C>[CH3:3][C@@:4]12[C@H:13]3[CH2:14][CH:15]=[C:16]4[C@@H:21]5[CH2:22][C:23]([CH3:26])([CH3:27])[CH2:24][CH2:25][C@:20]5([C:28]([O-:30])=[O:29])[CH2:19][CH2:18][C@@:17]4([CH3:31])[C@:12]3([CH3:32])[CH2:11][CH2:10][C@H:9]1[C:8]([CH3:34])([CH3:33])[C@@H:7]([OH:35])[CH2:6][CH2:5]2.[Na+:2]

参加物

6

反応物 4

HCID 962WaterHCID 6344DichloromethaneHCID 10494Oleanolic Acid3 回HCID 14798Sodium Hydroxide4 回

生成物 1

HCID 49857633Sodium oleanolate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A 10% aqueous solution of sodium hydroxide is added to an almost saturated solution of oleanolic acid in a water immiscible solvent, for example dichloromethane or diethyl ether. The volume of the sodium hydroxide solution is controlled by the amount of oleanolic acid taken; the final mixture should contain at least one, preferably 1,5 to 3, mole sodium hydroxide per mole oleanolic acid--a large excess of the sodium hydroxide solution may lower the yield. The mixture is mixed well (vigorous stirring or shaking) and the precipitated sodium oleanolate is separated. The sodium oleanolate can be recrystallised from aqueous organic solvents, preferably aqueous methanol or aqueous ethanol.

後処理

  1. additionThe mixture is mixed well
  2. customthe precipitated sodium oleanolate is separated
  3. customThe sodium oleanolate can be recrystallised from aqueous organic solvents, preferably aqueous methanol or aqueous ethanol

出典と根拠

ORDレコード
ord-72e40d7f526c429e96875cde66ff49b2
出典データセット
uspto-grants-1988_06
特許番号
US04752606

反応ノート

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